About SPRAS

SPRAS, short for “Signaling Pathway Reconstruction Analysis Streamliner” is a work-in-progress dockerized library of pathway reconstruction enhancement tools. The framework will contain different pathway reconstruction algorithms that connect genes and proteins of interest in the context of a general protein-protein interaction network, allowing users to run multiple algorithms on their inputs. See the registered report or GLBIO 2021 slides or video for more information.

Citation

A framework for benchmarking pathway reconstruction algorithms

Neha Talluri, Tristan Figueroa-Reid, Justin Hiemstra, Chris S Magnano, Adam Shedivy, Nistha Panda, Yancheng Liu, Sumedha Sanjeev, Oliver Faulkner Anderson, Altaf Barelvi, Aden O’Brien, Olivia T Johnson, James A Haddad, Spencer A Halberg-Spencer, Akniyet Nurbol, Iris Jan, Mahunan Degbelo, Daniel Nachreiner, Canek Llera-Magord, Gabriel Howland, Grace H Li, Anna Ritz⁺, Anthony Gitter⁺.

bioRxiv, 2026. doi:10.64898/2026.08.04.742550

⁺ denotes equal contribution.